Myelin protein zero

MPZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OAI
Identifiers
Aliases	MPZ, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0, myelin protein zero, CHN2
External IDs	OMIM: 159440; MGI: 103177; HomoloGene: 445; GeneCards: MPZ; OMA:MPZ - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,309,968 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	170,988,699 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; sural nerve; ; olfactory bulb; ; trigeminal ganglion; ; spinal ganglia; ; muscle layer of sigmoid colon; ; left coronary artery; ; right auricle of heart; ; testicle; ; seminal vesicula;
	Top expressed in
	somatic nerve plexus; ; lumbosacral plexus; ; sciatic nerve; ; utricle; ; ankle; ; lip; ; brachial plexus; ; vestibular sensory epithelium; ; esophagus; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity;
Cellular component	integral component of membrane; myelin sheath; rough endoplasmic reticulum; lysosome; basolateral plasma membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	negative regulation of apoptotic process; chemical synaptic transmission; myelination; cell-cell adhesion via plasma-membrane adhesion molecules; cell aggregation;
	Sources:Amigo / QuickGO
Orthologs
	4359
	17528
	ENSG00000158887
	ENSMUSG00000056569
	P25189
	P27573
	NM_000530; NM_001315491
	NM_008623; NM_001315499; NM_001315500
	NP_000521; NP_001302420
	NP_001302428; NP_001302429; NP_032649
	Wikidata
View/Edit Human	View/Edit Mouse

Myelin protein zero (MPZ), also Myelin protein P0, is a single membrane glycoprotein which in humans is encoded by the MPZ gene. P0 is a major structural component of the myelin sheath in the peripheral nervous system (PNS). Myelin protein zero is expressed by Schwann cells and accounts for over 50% of all proteins in the peripheral nervous system, making it the most common protein expressed in the PNS. Mutations in myelin protein zero can cause myelin deficiency and are associated with neuropathies like Charcot–Marie–Tooth disease and Dejerine–Sottas disease.