MRE11A

MRE11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3T1I
Identifiers
Aliases	MRE11, ATLD, HNGS1, MRE11B, MRE11A, MRE11 homolog A, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease
External IDs	OMIM: 600814; MGI: 1100512; HomoloGene: 4083; GeneCards: MRE11; OMA:MRE11 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	94,493,885 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,748,419 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; oocyte; ; secondary oocyte; ; testicle; ; sural nerve; ; gonad; ; epithelium of colon; ; monocyte; ; rectum; ; ventricular zone;
	Top expressed in
	ectoderm; ; otic vesicle; ; otic placode; ; spermatid; ; spermatocyte; ; saccule; ; epiblast; ; tail of embryo; ; primitive streak; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; manganese ion binding; DNA helicase activity; single-stranded DNA endodeoxyribonuclease activity; protein C-terminus binding; protein binding; 3'-5' exonuclease activity; nuclease activity; endonuclease activity; double-stranded DNA binding; endodeoxyribonuclease activity; exonuclease activity; hydrolase activity; cadherin binding; identical protein binding; 3'-5'-exodeoxyribonuclease activity; 5'-3' exonuclease activity;
Cellular component	site of double-strand break; cytosol; PML body; nucleus; cytoplasm; nucleoplasm; telomere; chromosome; Mre11 complex; replication fork;
Biological process	reciprocal meiotic recombination; DNA recombination; telomere maintenance via telomerase; positive regulation of kinase activity; mitotic intra-S DNA damage checkpoint signaling; telomeric 3' overhang formation; negative regulation of apoptotic process; chromosome organization; sister chromatid cohesion; cellular response to DNA damage stimulus; positive regulation of telomere maintenance; DNA duplex unwinding; homologous chromosome pairing at meiosis; negative regulation of DNA endoreduplication; double-strand break repair; meiosis; double-strand break repair via homologous recombination; positive regulation of protein autophosphorylation; cell population proliferation; mitotic G2 DNA damage checkpoint signaling; viral process; double-strand break repair via nonhomologous end joining; positive regulation of type I interferon production; regulation of mitotic recombination; DNA repair; nucleic acid phosphodiester bond hydrolysis; DNA double-strand break processing; strand displacement; DNA replication; DNA synthesis involved in DNA repair; regulation of signal transduction by p53 class mediator; telomere maintenance; meiotic DNA double-strand break formation; mitochondrial double-strand break repair via homologous recombination; DNA strand resection involved in replication fork processing;
	Sources:Amigo / QuickGO
Orthologs
	4361
	17535
	ENSG00000020922
	ENSMUSG00000031928
	P49959
	Q61216
	NM_005590; NM_005591; NM_001330347
	NM_018736; NM_001310728
	NP_001317276; NP_005581; NP_005582
	NP_001297657; NP_061206
	Wikidata
View/Edit Human	View/Edit Mouse

Double-strand break repair protein MRE11 (Meiotic recombination 11) is an enzyme that in humans is encoded by the MRE11 gene. The gene has been designated MRE11A to distinguish it from the pseudogene MRE11B that is nowadays named MRE11P1.