Mitochondrial ribosomal protein L15

MRPL15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL15, L15mt, MRP-L15, MRP-L7, RPML7, HSPC145, mitochondrial ribosomal protein L15
External IDs	OMIM: 611828; MGI: 1351639; HomoloGene: 32210; GeneCards: MRPL15; OMA:MRPL15 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	54,148,514 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	4,855,962 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; vastus lateralis muscle; ; biceps brachii; ; muscle of thigh; ; gastrocnemius muscle; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; triceps brachii muscle; ; left ventricle; ; gonad;
	Top expressed in
	morula; ; sternocleidomastoid muscle; ; embryo; ; digastric muscle; ; muscle of thigh; ; temporal muscle; ; epiblast; ; extraocular muscle; ; embryo; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; RNA binding;
Cellular component	mitochondrial inner membrane; large ribosomal subunit; ribosome; mitochondrion; mitochondrial large ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	29088
	27395
	ENSG00000137547
	ENSMUSG00000033845
	Q9P015
	Q9CPR5
	NM_014175
	NM_001177658; NM_025300
	NP_054894
	NP_001171129; NP_079576
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q.