Mitochondrial ribosomal protein L17

MRPL17
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQM, 3J7Y, 3J9M
Identifiers
Aliases	MRPL17, L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26, mitochondrial ribosomal protein L17
External IDs	OMIM: 611830; MGI: 1351608; HomoloGene: 32526; GeneCards: MRPL17; OMA:MRPL17 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,683,340 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,460,306 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; apex of heart; ; anterior pituitary; ; left adrenal gland; ; right ventricle; ; right adrenal gland; ; left adrenal cortex; ; gonad; ; right adrenal cortex; ; muscle of thigh;
	Top expressed in
	blastocyst; ; embryo; ; embryo; ; yolk sac; ; morula; ; right kidney; ; otic placode; ; lip; ; muscle of thigh; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; protein domain specific binding;
Cellular component	ribosome; intracellular anatomical structure; mitochondrion; mitochondrial large ribosomal subunit; mitochondrial inner membrane;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis; mitochondrial genome maintenance;
	Sources:Amigo / QuickGO
Orthologs
	63875
	27397
	ENSG00000158042
	ENSMUSG00000030879
	Q9NRX2
	Q9D8P4
	NM_022061
	NM_025301
	NP_071344
	NP_079577
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.