Mitochondrial ribosomal protein L37

MRPL37
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL37, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt
External IDs	OMIM: 611843; MGI: 1926268; HomoloGene: 9536; GeneCards: MRPL37; OMA:MRPL37 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	54,225,464 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	106,924,065 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; right adrenal gland; ; skin of arm; ; right adrenal cortex; ; tibialis anterior muscle; ; left ventricle; ; right lobe of liver; ; left adrenal gland; ; apex of heart;
	Top expressed in
	genital tubercle; ; tail of embryo; ; muscle of thigh; ; right kidney; ; ventricular zone; ; embryo; ; lip; ; skeletal muscle tissue; ; embryo; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrial large ribosomal subunit; mitochondrion;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	51253
	56280
	ENSG00000116221
	ENSMUSG00000028622
	Q9BZE1
	Q921S7
	NM_016491; NM_001330602
	NM_025500
	NP_001317531; NP_057575
	NP_079776
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.