Mitochondrial ribosomal protein L39

MRPL39
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL39, C21orf92, L39mt, MRP-L5, MRPL5, PRED22, PRED66, RPML5, MSTP003, mitochondrial ribosomal protein L39, L5mt
External IDs	OMIM: 611845; MGI: 1351620; HomoloGene: 9679; GeneCards: MRPL39; OMA:MRPL39 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	25,607,517 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	84,532,630 bp
RNA expression pattern
	Top expressed in
	oocyte; ; tendon of biceps brachii; ; left ventricle; ; right adrenal gland; ; Achilles tendon; ; right adrenal cortex; ; gastrocnemius muscle; ; secondary oocyte; ; muscle of thigh; ; left testis;
	Top expressed in
	fossa; ; condyle; ; seminiferous tubule; ; facial motor nucleus; ; motor neuron; ; right ventricle; ; primitive streak; ; Paneth cell; ; medial ganglionic eminence; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrial large ribosomal subunit; mitochondrion;
Biological process	mitochondrial translational elongation; mitochondrial translational termination;
	Sources:Amigo / QuickGO
Orthologs
	54148
	27393
	ENSG00000154719
	ENSMUSG00000022889
	Q9NYK5
	Q9JKF7
	NM_017446; NM_080794
	NM_017404; NM_001384093; NM_001384095; NM_001384096
	NP_059142; NP_542984
	NP_059100; NP_001371022; NP_001371024; NP_001371025
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.