MRPS22

MRPS22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J9M
Identifiers
Aliases	MRPS22, C3orf5, COXPD5, GIBT, MRP-S22, RPMS22, GK002, mitochondrial ribosomal protein S22, ODG7
External IDs	OMIM: 605810; MGI: 1928137; HomoloGene: 57030; GeneCards: MRPS22; OMA:MRPS22 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	139,360,497 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	98,483,713 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; gonad; ; Achilles tendon; ; tibialis anterior muscle; ; left adrenal gland; ; endothelial cell; ; myocardium of left ventricle; ; deltoid muscle; ; left adrenal cortex;
	Top expressed in
	primary oocyte; ; medial ganglionic eminence; ; maxillary prominence; ; mandibular prominence; ; abdominal wall; ; renal corpuscle; ; facial motor nucleus; ; medullary collecting duct; ; ureter; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrion; mitochondrial small ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; biological process;
	Sources:Amigo / QuickGO
Orthologs
	56945
	64655
	ENSG00000175110
	ENSMUSG00000032459
	P82650
	Q9CXW2
	NM_020191; NM_001363857; NM_001363893
	NM_025485
	NP_064576; NP_001350786; NP_001350822
	NP_079761
	Wikidata
View/Edit Human	View/Edit Mouse

28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.