MSH6

MSH6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2O8F, 2GFU, 2O8B, 2O8C, 2O8D, 2O8E
Identifiers
Aliases	MSH6, mutS homolog 6, GTBP, GTMBP, HNPCC5, HSAP, p160, MMRCS3, MSH-6
External IDs	OMIM: 600678; MGI: 1343961; HomoloGene: 149; GeneCards: MSH6; OMA:MSH6 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	47,810,063 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	88,298,320 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; ganglionic eminence; ; secondary oocyte; ; gonad; ; ovary; ; tendon of biceps brachii; ; left ovary; ; cartilage tissue; ; Achilles tendon;
	Top expressed in
	zygote; ; epiblast; ; secondary oocyte; ; primitive streak; ; primary oocyte; ; tail of embryo; ; genital tubercle; ; abdominal wall; ; Gonadal ridge; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; protein homodimerization activity; mismatched DNA binding; ADP binding; chromatin binding; oxidized purine DNA binding; methylated histone binding; damaged DNA binding; ATPase activity; protein binding; single thymine insertion binding; four-way junction DNA binding; MutLalpha complex binding; double-stranded DNA binding; ATP binding; magnesium ion binding; single guanine insertion binding; guanine/thymine mispair binding; ATP-dependent activity, acting on DNA; enzyme binding;
Cellular component	Golgi apparatus; intracellular membrane-bounded organelle; MutSalpha complex; nucleoplasm; chromosome; nucleus; cytosol; mismatch repair complex;
Biological process	determination of adult lifespan; cellular response to DNA damage stimulus; positive regulation of isotype switching; intrinsic apoptotic signaling pathway; maintenance of DNA repeat elements; positive regulation of helicase activity; somatic recombination of immunoglobulin gene segments; negative regulation of DNA recombination; DNA mismatch repair; viral process; DNA repair; meiotic mismatch repair; intrinsic apoptotic signaling pathway in response to DNA damage; response to UV; somatic hypermutation of immunoglobulin genes; isotype switching; pyrimidine dimer repair; mitotic G2 DNA damage checkpoint signaling; negative regulation of DNA endoreduplication; interstrand cross-link repair; replication fork arrest;
	Sources:Amigo / QuickGO
Orthologs
	2956
	17688
	ENSG00000116062
	ENSMUSG00000005370
	P52701
	P54276
	NM_000179; NM_001281492; NM_001281493; NM_001281494
	NM_010830
	NP_000170; NP_001268421; NP_001268422; NP_001268423
	NP_034960
	Wikidata
View/Edit Human	View/Edit Mouse

MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of the human "G/T binding protein," (GTBP) also called p160 or hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair.

Defects in hMSH6 are associated with atypical hereditary nonpolyposis colorectal cancer not fulfilling the Amsterdam criteria for HNPCC. hMSH6 mutations have also been linked to endometrial cancer and the development of endometrial carcinomas.