SEPX1

MSRB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MAO
Identifiers
Aliases	MSRB1, SELR, SELX, SEPX1, SepR, HSPC270, methionine sulfoxide reductase B1, SELENOX, SELENOR
External IDs	OMIM: 606216; MGI: 1351642; HomoloGene: 8455; GeneCards: MSRB1; OMA:MSRB1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,943,199 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,961,752 bp
RNA expression pattern
	Top expressed in
	blood; ; right lobe of liver; ; body of pancreas; ; trabecular bone; ; thoracic diaphragm; ; monocyte; ; granulocyte; ; bone marrow; ; periodontal fiber; ; human kidney;
	Top expressed in
	granulocyte; ; left lobe of liver; ; parotid gland; ; sternocleidomastoid muscle; ; temporal muscle; ; triceps brachii muscle; ; tibiofemoral joint; ; interventricular septum; ; stroma of bone marrow; ; digastric muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; oxidoreductase activity; actin binding; zinc ion binding; metal ion binding; methionine-R-sulfoxide reductase activity; peptide-methionine (R)-S-oxide reductase activity; L-methionine-(R)-S-oxide reductase activity; protein binding;
Cellular component	cytoplasm; cytosol; cytoskeleton; nucleus; actin cytoskeleton; cellular component;
Biological process	immune system process; actin filament polymerization; innate immune response; response to oxidative stress; protein repair;
	Sources:Amigo / QuickGO
Orthologs
	51734
	27361
	ENSG00000198736
	ENSMUSG00000075705
	Q9NZV6
	Q9JLC3
	NM_016332; NM_001382264; NM_001382265
	NM_013759; NM_001346668
	NP_057416; NP_001369193; NP_001369194
	NP_001333597; NP_038787
	Wikidata
View/Edit Human	View/Edit Mouse

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.