Homeobox protein MSX-1

MSX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IG7
Identifiers
Aliases	MSX1, ECTD3, HOX7, HYD1, STHAG1, msh homeobox 1
External IDs	OMIM: 142983; MGI: 97168; HomoloGene: 1836; GeneCards: MSX1; OMA:MSX1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	4,863,936 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	37,981,927 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Epithelium of choroid plexus; ; canal of the cervix; ; periodontal fiber; ; saphenous vein; ; endometrium; ; oocyte; ; vena cava; ; secondary oocyte; ; urethra;
	Top expressed in
	desmocranium; ; choroid plexus of fourth ventricle; ; dental papilla; ; Epithelium of choroid plexus; ; hand; ; amnion; ; maxillary prominence; ; lateral nasal prominence; ; abdominal wall; ; maxillary part of mouth;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; DNA-binding transcription activator activity, RNA polymerase II-specific; p53 binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	anterior/posterior pattern specification; negative regulation of cell population proliferation; negative regulation of striated muscle cell differentiation; signal transduction involved in regulation of gene expression; regulation of odontogenesis; negative regulation of transcription regulatory region DNA binding; stem cell differentiation; positive regulation of mesenchymal cell apoptotic process; mammary gland epithelium development; negative regulation of apoptotic process; activation of meiosis; positive regulation of BMP signaling pathway; transcription, DNA-templated; cartilage morphogenesis; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; multicellular organism development; odontogenesis; bone morphogenesis; embryonic limb morphogenesis; BMP signaling pathway; middle ear morphogenesis; mesenchymal cell proliferation; embryonic forelimb morphogenesis; negative regulation of DNA binding; positive regulation of DNA damage response, signal transduction by p53 class mediator; heart morphogenesis; BMP signaling pathway involved in heart development; cell morphogenesis; heart development; forebrain development; muscle organ development; negative regulation of transcription by RNA polymerase II; roof of mouth development; embryonic digit morphogenesis; in utero embryonic development; protein stabilization; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; epithelial to mesenchymal transition involved in endocardial cushion formation; transcription by RNA polymerase II; negative regulation of cell growth; epithelial to mesenchymal transition; embryonic hindlimb morphogenesis; negative regulation of transcription, DNA-templated; protein localization to nucleus; midbrain development; odontogenesis of dentin-containing tooth; embryonic nail plate morphogenesis; face morphogenesis; pituitary gland development; cellular response to nicotine; cartilage development; embryonic morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4487
	17701
	ENSG00000163132
	ENSMUSG00000048450
	P28360
	P13297
	NM_002448
	NM_010835
	NP_002439
	NP_034965
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein MSX-1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to thyroid hormone. MSX1 is also expressed in highly differentiated pituitary cells which until recently was thought to be expressed exclusively during embryogenesis. There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell–cell interactions in the embryo suggest that they have a pivotal role during early development.