MT-ATP6

ATP6
Identifiers
Aliases	ATP6, ATPase6, MTATP synthase Fo subunit 6
External IDs	OMIM: 516060; MGI: 99927; HomoloGene: 5012; GeneCards: ATP6; OMA:ATP6 - orthologs
Gene location (Human)
Chr.	Mitochondrial DNA (human)
End	9,207 bp
Gene location (Mouse)
Chr.	Mitochondrial DNA (mouse)
End	8,607 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; gastric mucosa; ; Descending thoracic aorta; ; right hemisphere of cerebellum; ; body of uterus; ; mucosa of transverse colon; ; prostate; ; right ovary; ; right lung; ; muscle layer of sigmoid colon;
	Top expressed in
	epiblast; ; primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; muscle of thigh; ; renal cortex; ; proximal tubule; ; ventricular zone; ; ganglionic eminence; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase activity; transmembrane transporter activity; proton transmembrane transporter activity; protein binding; proton-transporting ATP synthase activity, rotational mechanism;
Cellular component	integral component of membrane; mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrion; membrane; proton-transporting ATP synthase complex, coupling factor F(o); proton-transporting ATP synthase complex;
Biological process	response to hyperoxia; mitochondrial ATP synthesis coupled proton transport; ageing; ATP synthesis coupled proton transport; ion transport; ATP biosynthetic process; cristae formation;
	Sources:Amigo / QuickGO
Orthologs
	4508
	17705
	ENSG00000198899
	ENSMUSG00000064357
	P00846
	P00848
	n/a
	n/a
	n/a
	NP_904333
	Wikidata
View/Edit Human	View/Edit Mouse

MT-ATP6 (or ATP6) is a mitochondrial gene with the full name 'mitochondrially encoded ATP synthase membrane subunit 6' that encodes the ATP synthase F_o subunit 6 (or subunit/chain A). This subunit belongs to the F_o complex of the large, transmembrane F-type ATP synthase. This enzyme, which is also known as complex V, is responsible for the final step of oxidative phosphorylation in the electron transport chain. Specifically, one segment of ATP synthase allows positively charged ions, called protons, to flow across a specialized membrane inside mitochondria. Another segment of the enzyme uses the energy created by this proton flow to convert a molecule called adenosine diphosphate (ADP) to ATP. Mutations in the MT-ATP6 gene have been found in approximately 10 to 20 percent of people with Leigh syndrome.