MT-ATP8

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ATP synthase protein 8 (metazoa)
ATP synthase protein 8 (metazoa)
Identifiers
Symbol	ATP-synt_8
Pfam	PF00895
Pfam clan	CL0255
InterPro	IPR001421
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ATP8
Identifiers
Aliases	ATP8, ATPase8, MTMT-ATP synthase F0 subunit 8
External IDs	OMIM: 516070; MGI: 99926; HomoloGene: 124425; GeneCards: ATP8; OMA:ATP8 - orthologs
Gene location (Human)
Chr.	Mitochondrial DNA (human)
End	8,572 bp
Gene location (Mouse)
Chr.	Mitochondrial DNA (mouse)
End	7,969 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right lung; ; Descending thoracic aorta; ; gastrocnemius muscle; ; right ovary; ; olfactory zone of nasal mucosa; ; right adrenal cortex; ; superior frontal gyrus; ; subcutaneous adipose tissue; ; left adrenal gland;
	Top expressed in
	striatum of neuraxis; ; ventricular zone; ; ganglionic eminence; ; Hypothalamus; ; neural tube; ; urinary bladder; ; dentate gyrus of hippocampal formation granule cell; ; white adipose tissue; ; adrenal gland; ; zone of skin;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase activity; transmembrane transporter activity; proton transmembrane transporter activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); mitochondrion; membrane; mitochondrial membranes; proton-transporting ATP synthase complex, coupling factor F(o); mitochondrial proton-transporting ATP synthase complex;
Biological process	mitochondrial ATP synthesis coupled proton transport; ATP synthesis coupled proton transport; ion transport; ATP biosynthetic process; cristae formation;
	Sources:Amigo / QuickGO
Orthologs
	4509
	17706
	ENSG00000228253
	ENSMUSG00000064356
	P03928
	P03930
	n/a
	n/a
	n/a
	NP_904332
	Wikidata
View/Edit Human	View/Edit Mouse

Plant ATP synthase F0 subunit 8

Identifiers

Symbol

YMF19

Pfam clan

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Fungal ATP synthase protein 8 (A6L)

Identifiers

Symbol

Fun_ATP-synt_8

Pfam clan

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

MT-ATP8 (or ATP8) is a mitochondrial gene with the full name 'mitochondrially encoded ATP synthase membrane subunit 8' that encodes a subunit of mitochondrial ATP synthase, ATP synthase F_o subunit 8 (or subunit A6L). This subunit belongs to the F_o complex of the large, transmembrane F-type ATP synthase. This enzyme, which is also known as complex V, is responsible for the final step of oxidative phosphorylation in the electron transport chain. Specifically, one segment of ATP synthase allows positively charged ions, called protons, to flow across a specialized membrane inside mitochondria. Another segment of the enzyme uses the energy created by this proton flow to convert a molecule called adenosine diphosphate (ADP) to ATP. Subunit 8 differs in sequence between Metazoa, plants and Fungi.