MT-ND1

ND1

Identifiers

ND1, MTMT-NADH dehydrogenase, subunit 1 (complex I), NADH dehydrogenase subunit 1

External IDs

OMIM: 516000; MGI: 101787; HomoloGene: 5011; GeneCards: ND1; OMA:ND1 - orthologs

Gene location (Human)

Chr.	Mitochondrial DNA (human)

Band	n/a	Start	3,307 bp
Band	n/a	End	4,262 bp

Gene location (Mouse)

Chr.	Mitochondrial DNA (mouse)

Band	n/a	Start	2,751 bp
Band	n/a	End	3,707 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

subcutaneous adipose tissue

right hemisphere of cerebellum

right testis

right frontal lobe

left testis

gastrocnemius muscle

superior frontal gyrus

primary visual cortex

olfactory zone of nasal mucosa

prefrontal cortex

Top expressed in

tail of embryo

striatum of neuraxis

olfactory bulb

yolk sac

Cerebellum

primary visual cortex

Hypothalamus

genital tubercle

superior frontal gyrus

right kidney

More reference expression data

n/a

Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity oxidoreductase activity protein binding NADH dehydrogenase activity
Cellular component	integral component of membrane mitochondrial inner membrane mitochondrial respiratory chain complex I soma dendrite respirasome mitochondrial membranes mitochondrion membrane
Biological process	response to hydroperoxide response to organic cyclic compound mitochondrial respiratory chain complex I assembly mitochondrial electron transport, NADH to ubiquinone cellular respiration aerobic respiration
Sources:Amigo / QuickGO

Species

Human

Mouse


4535


17716


ENSG00000198888


ENSMUSG00000064341


P03886


P03888

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


NP_904328

Location (UCSC)

Chr M: 0 – 0 Mb

Chr M: 0 – 0 Mb

PubMed search

View/Edit Human

View/Edit Mouse

MT-ND1 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 1 (ND1) protein. The ND1 protein is a subunit of NADH dehydrogenase, which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of the human MT-ND1 gene are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), Leigh's syndrome (LS), Leber's hereditary optic neuropathy (LHON) and increases in adult BMI.