MT-ND2

ND2

Identifiers

ND2, complex I ND2 subunit, NAD2, NADH-ubiquinone oxidoreductase chain 2, MT-MTNADH dehydrogenase subunit 2

External IDs

OMIM: 516001; MGI: 102500; HomoloGene: 5019; GeneCards: ND2; OMA:ND2 - orthologs

Gene location (Human)

Chr.	Mitochondrial DNA (human)

Band	n/a	Start	4,470 bp
Band	n/a	End	5,511 bp

Gene location (Mouse)

Chr.	Mitochondrial DNA (mouse)

Band	n/a	Start	3,914 bp
Band	n/a	End	4,951 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

subcutaneous adipose tissue

caudate nucleus

putamen

lactiferous gland

right uterine tube

C1 segment

muscle layer of sigmoid colon

left uterine tube

right hemisphere of cerebellum

substantia nigra

Top expressed in

dentate gyrus of hippocampal formation granule cell

Hypothalamus

striatum of neuraxis

primary visual cortex

superior frontal gyrus

cerebellar cortex

adrenal gland

hippocampus proper

neural layer of retina

esophagus

More reference expression data

n/a

Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity oxidoreductase activity protein kinase binding ionotropic glutamate receptor binding
Cellular component	respirasome membrane postsynaptic density integral component of membrane mitochondrion mitochondrial respiratory chain complex I mitochondrial inner membrane
Biological process	mitochondrial respiratory chain complex I assembly reactive oxygen species metabolic process mitochondrial electron transport, NADH to ubiquinone
Sources:Amigo / QuickGO

Species

Human

Mouse


4536


17717


ENSG00000198763


ENSMUSG00000064345


P03891


P03893

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


NP_904329

Location (UCSC)

Chr M: 0 – 0.01 Mb

Chr M: 0 – 0 Mb

PubMed search

View/Edit Human

View/Edit Mouse

MT-ND2 is a gene of the mitochondrial genome coding for the NADH dehydrogenase 2 (ND2) protein. The ND2 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of human MT-ND2 are associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), Leigh's syndrome (LS), Leber's hereditary optic neuropathy (LHON) and increases in adult BMI.