MT-ND3

ND3

Identifiers

ND3, MTMT-NADH dehydrogenase, subunit 3 (complex I), NADH dehydrogenase subunit 3

External IDs

OMIM: 516002; MGI: 102499; HomoloGene: 5018; GeneCards: ND3; OMA:ND3 - orthologs

Gene location (Human)

Chr.	Mitochondrial DNA (human)

Band	n/a	Start	10,059 bp
Band	n/a	End	10,404 bp

Gene location (Mouse)

Chr.	Mitochondrial DNA (mouse)

Band	n/a	Start	9,459 bp
Band	n/a	End	9,806 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right uterine tube

right auricle of heart

granulocyte

Brodmann area 9

muscle layer of sigmoid colon

lactiferous gland

subcutaneous adipose tissue

right adrenal gland

left adrenal cortex

prostate

Top expressed in

Hypothalamus

hippocampus proper

olfactory bulb

lip

quadriceps femoris muscle

islet of Langerhans

superior frontal gyrus

duodenum

neural layer of retina

muscle of thigh

More reference expression data

n/a

Gene ontology
Molecular function	oxidoreductase activity protein binding NADH dehydrogenase (ubiquinone) activity
Cellular component	integral component of membrane mitochondrial inner membrane mitochondrial respiratory chain complex I respirasome membrane mitochondrion mitochondrial membranes NADH dehydrogenase complex
Biological process	response to hormone response to light intensity cellular response to glucocorticoid stimulus response to oxidative stress mitochondrial respiratory chain complex I assembly mitochondrial electron transport, NADH to ubiquinone
Sources:Amigo / QuickGO

Species

Human

Mouse


4537


17718


ENSG00000198840


ENSMUSG00000064360


P03897


P03899

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


NP_904335

Location (UCSC)

Chr M: 0.01 – 0.01 Mb

Chr M: 0.01 – 0.01 Mb

PubMed search

View/Edit Human

View/Edit Mouse

MT-ND3 is a gene of the mitochondrial genome coding for the NADH dehydrogenase 3 (ND3) protein. The ND3 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of MT-ND3 are associated with Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), Leigh's syndrome (LS) and Leber's hereditary optic neuropathy (LHON).