MT-ND4

ND4

Identifiers

ND4, MTMT-NADH dehydrogenase, subunit 4 (complex I), NADH dehydrogenase subunit 4

External IDs

OMIM: 516003; MGI: 102498; HomoloGene: 38240; GeneCards: ND4; OMA:ND4 - orthologs

Gene location (Human)

Chr.	Mitochondrial DNA (human)

Band	n/a	Start	10,760 bp
Band	n/a	End	12,137 bp

Gene location (Mouse)

Chr.	Mitochondrial DNA (mouse)

Band	n/a	Start	10,167 bp
Band	n/a	End	11,544 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right uterine tube

apex of heart

right adrenal gland

right lung

left uterine tube

right adrenal cortex

left adrenal cortex

right testis

canal of the cervix

right ovary

Top expressed in

Hypothalamus

dentate gyrus of hippocampal formation granule cell

primary visual cortex

superior frontal gyrus

cerebellar cortex

adrenal gland

hippocampus proper

zone of skin

striatum of neuraxis

human kidney

More reference expression data


More reference expression data

Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity oxidoreductase activity NADH dehydrogenase activity ubiquinone binding
Cellular component	integral component of membrane membrane mitochondrial membranes mitochondrial respiratory chain complex I mitochondrion mitochondrial inner membrane respirasome
Biological process	response to hypoxia response to nicotine ageing ATP synthesis coupled electron transport in utero embryonic development cerebellum development mitochondrial respiratory chain complex I assembly response to ethanol mitochondrial electron transport, NADH to ubiquinone aerobic respiration electron transport coupled proton transport
Sources:Amigo / QuickGO

Species

Human

Mouse


4538


17719


ENSG00000198886


ENSMUSG00000064363


P03905


P03911

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


NP_904337

Location (UCSC)

Chr M: 0.01 – 0.01 Mb

Chr M: 0.01 – 0.01 Mb

PubMed search

View/Edit Human

View/Edit Mouse

MT-ND4 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 4 (ND4) protein. The ND4 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variations in the MT-ND4 gene are associated with age-related macular degeneration (AMD), Leber's hereditary optic neuropathy (LHON), mesial temporal lobe epilepsy (MTLE) and cystic fibrosis.