MT-ND4L

ND4L
Identifiers
Aliases	ND4L, MTMT-NADH dehydrogenase, subunit 4L (complex I), NADH dehydrogenase subunit 4L
External IDs	OMIM: 516004; MGI: 102497; HomoloGene: 5021; GeneCards: ND4L; OMA:ND4L - orthologs
Gene location (Human)
Chr.	Mitochondrial DNA (human)
End	10,766 bp
Gene location (Mouse)
Chr.	Mitochondrial DNA (mouse)
End	10,173 bp
RNA expression pattern
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; rectum; ; apex of heart; ; renal cortex; ; muscle of thigh; ; right uterine tube; ; right lobe of thyroid gland; ; left adrenal cortex; ; olfactory zone of nasal mucosa;
	Top expressed in
	cerebellar cortex; ; superior frontal gyrus; ; neural layer of retina; ; adrenal gland; ; primary visual cortex; ; Hypothalamus; ; muscle of thigh; ; striatum of neuraxis; ; hippocampus proper; ; zone of skin;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on NAD(P)H; oxidoreductase activity; NADH dehydrogenase (ubiquinone) activity;
Cellular component	integral component of membrane; respirasome; membrane; mitochondrion; mitochondrial membranes; mitochondrial respiratory chain complex I; NADH dehydrogenase complex;
Biological process	ATP synthesis coupled electron transport; mitochondrial electron transport, NADH to ubiquinone;
	Sources:Amigo / QuickGO
Orthologs
	4539
	17720
	ENSG00000212907
	ENSMUSG00000065947
	P03901
	P03903
	n/a
	n/a
	n/a
	NP_904336
	Wikidata
View/Edit Human	View/Edit Mouse

MT-ND4L is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 4L (ND4L) protein. The ND4L protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of human MT-ND4L are associated with increased BMI in adults and Leber's Hereditary Optic Neuropathy (LHON).