MT-ND6

ND6
Identifiers
Aliases	ND6, MTMT-NADH dehydrogenase, subunit 6 (complex I), NADH dehydrogenase subunit 6
External IDs	OMIM: 516006; MGI: 102495; HomoloGene: 5022; GeneCards: ND6; OMA:ND6 - orthologs
Gene location (Human)
Chr.	Mitochondrial DNA (human)
End	14,673 bp
Gene location (Mouse)
Chr.	Mitochondrial DNA (mouse)
End	14,070 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; left uterine tube; ; right uterine tube; ; right auricle of heart; ; granulocyte; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; Amygdala; ; fundus;
	Top expressed in
	neural layer of retina; ; adrenal gland; ; Hypothalamus; ; striatum of neuraxis; ; bone marrow; ; hippocampus proper; ; superior frontal gyrus; ; human kidney; ; cerebellar cortex; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity; oxidoreductase activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; respirasome; membrane; mitochondrial membranes; mitochondrion;
Biological process	response to cocaine; response to nicotine; response to hydrogen peroxide; mitochondrial respiratory chain complex I assembly; mitochondrial electron transport, NADH to ubiquinone;
	Sources:Amigo / QuickGO
Orthologs
	4541
	17722
	ENSG00000198695
	ENSMUSG00000064368
	P03923
	P03925
	n/a
	n/a
	n/a
	NP_904339
	Wikidata
View/Edit Human	View/Edit Mouse

MT-ND6 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 6 protein (ND6). The ND6 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variations in the human MT-ND6 gene are associated with Leigh's syndrome, Leber's hereditary optic neuropathy (LHON) and dystonia.