Metallothionein-3

MT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F5H, 2FJ4, 2FJ5
Identifiers
Aliases	MT3, GIF, GIFB, GRIF, Znmetallothionein 3
External IDs	OMIM: 139255; MGI: 97173; HomoloGene: 136800; GeneCards: MT3; OMA:MT3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,591,088 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	94,880,774 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; putamen; ; Brodmann area 9; ; temporal lobe; ; Amygdala; ; substantia nigra; ; caudate nucleus; ; right frontal lobe; ; prefrontal cortex; ; hippocampus proper;
	Top expressed in
	choroid plexus of fourth ventricle; ; dentate gyrus of hippocampal formation granule cell; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; primary visual cortex; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; superior colliculus; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; protein kinase activator activity; metal ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; antioxidant activity; protein binding; copper ion binding; cadmium ion binding;
Cellular component	cytoplasm; cytosol; rough endoplasmic reticulum; ribosome; astrocyte end-foot; postsynaptic density; synaptic vesicle; plasma membrane; dendritic spine; astrocyte projection; intracellular anatomical structure; mitochondrial outer membrane; axon; inclusion body; perinuclear region of cytoplasm; microtubule; extracellular space; nucleus;
Biological process	negative regulation of neuron apoptotic process; positive regulation of necrotic cell death; cellular lipid catabolic process; positive regulation of vascular endothelial growth factor receptor signaling pathway; activation of protein kinase B activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein phosphorylation; positive regulation of cell death; response to hypoxia; zinc ion homeostasis; protein kinase B signaling; histone modification; leptin-mediated signaling pathway; removal of superoxide radicals; astrocyte development; ERK1 and ERK2 cascade; negative regulation of neurogenesis; regulation of response to food; protein stabilization; zinc ion transport; response to metal ion; negative regulation of apoptotic process; positive regulation of catalytic activity; cholesterol catabolic process; cellular response to cadmium ion; cellular metal ion homeostasis; cadmium ion homeostasis; response to oxidative stress; negative regulation of hydrogen peroxide catabolic process; negative regulation of cysteine-type endopeptidase activity; positive regulation of transcription, DNA-templated; brain development; positive regulation of gene expression; positive regulation of lysosomal membrane permeability; cellular zinc ion homeostasis; negative regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; negative regulation of oxidoreductase activity; regulation of protein glycosylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of oxygen metabolic process; cellular response to oxidative stress; cellular response to nitric oxide; negative regulation of reactive oxygen species metabolic process; energy reserve metabolic process; cell population proliferation; negative regulation of autophagy; negative regulation of transcription, DNA-templated; negative regulation of axon extension; negative regulation of necrotic cell death; cellular response to hypoxia; negative regulation of neuron death; apoptotic process; detoxification of copper ion; cellular response to copper ion; cellular response to zinc ion; negative regulation of neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	4504
	17751
	ENSG00000087250
	ENSMUSG00000031760
	P25713
	P28184
	NM_005954
	NM_013603
	NP_005945
	NP_038631
	Wikidata
View/Edit Human	View/Edit Mouse

Metallothionein-3 (also known as Growth Inhibitory Factor) is a protein that in humans is encoded by the MT3 gene. It is a 68-amino acid peptide (20 of which are cysteine) that is abnormally under-expressed in the brains of patients with Alzheimer's disease. Metallothionein-3 is a member of the metallothionein family of proteins.