MTA1

MTA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BKX, 4PBY, 4PBZ, 4PC0, 5ICN, 5FXY
Identifiers
Aliases	MTA1, metastasis associated 1
External IDs	OMIM: 603526; MGI: 2150037; HomoloGene: 3442; GeneCards: MTA1; OMA:MTA1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	105,470,729 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	113,100,826 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; apex of heart; ; right ovary; ; left ovary; ; right hemisphere of cerebellum; ; left uterine tube; ; canal of the cervix; ; anterior pituitary;
	Top expressed in
	somite; ; tail of embryo; ; ventricular zone; ; epiblast; ; genital tubercle; ; mandibular prominence; ; molar; ; maxillary prominence; ; yolk sac; ; hand;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; transcription coactivator activity; zinc ion binding; chromatin binding; metal ion binding; core promoter sequence-specific DNA binding; protein binding; histone deacetylase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; histone deacetylase binding;
Cellular component	cytoplasm; nuclear envelope; intracellular membrane-bounded organelle; nucleoplasm; microtubule; cytoskeleton; nucleus; cytosol; NuRD complex;
Biological process	response to ionizing radiation; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; rhythmic process; circadian regulation of gene expression; transcription, DNA-templated; positive regulation of protein autoubiquitination; double-strand break repair; entrainment of circadian clock by photoperiod; signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; locomotor rhythm; histone deacetylation; negative regulation of nucleic acid-templated transcription; regulation of transcription by RNA polymerase II; positive regulation of nucleic acid-templated transcription; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9112
	116870
	ENSG00000182979
	ENSMUSG00000021144
	Q13330
	Q8K4B0
	NM_001203258; NM_004689
NM_054081; NM_001346696; NM_001364620; NM_001364621; NM_001364622;
	NM_001364623
	NP_001190187; NP_004680
NP_001333625; NP_473422; NP_001351549; NP_001351550; NP_001351551;
	NP_001351552
	Wikidata
View/Edit Human	View/Edit Mouse

Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. MTA1 is the founding member of the MTA family of genes. MTA1 is primarily localized in the nucleus but also found to be distributed in the extra-nuclear compartments. MTA1 is a component of several chromatin remodeling complexes including the nucleosome remodeling and deacetylation complex (NuRD). MTA1 regulates gene expression by functioning as a coregulator to integrate DNA-interacting factors to gene activity. MTA1 participates in physiological functions in the normal and cancer cells. MTA1 is one of the most upregulated proteins in human cancer and associates with cancer progression, aggressive phenotypes, and poor prognosis of cancer patients.