MTCH1

MTCH1
Identifiers
Aliases	MTCH1, CGI-64, PIG60, PSAP, SLC25A49, mitochondrial carrier 1
External IDs	OMIM: 610449; MGI: 1929261; HomoloGene: 22807; GeneCards: MTCH1; OMA:MTCH1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	36,986,298 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,566,908 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; inferior olivary nucleus; ; pancreatic ductal cell; ; dorsal motor nucleus of vagus nerve; ; entorhinal cortex; ; corpus epididymis; ; Epithelium of choroid plexus; ; superior frontal gyrus;
	Top expressed in
	saccule; ; dentate gyrus of hippocampal formation granule cell; ; vestibular membrane of cochlear duct; ; otic placode; ; otic vesicle; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; lateral septal nucleus; ; molar; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; intracellular anatomical structure; mitochondrial inner membrane; mitochondrion; membrane;
Biological process	regulation of signal transduction; apoptotic process; positive regulation of apoptotic process; neuronal ion channel clustering; activation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	23787
	56462
	ENSG00000137409
	ENSMUSG00000024012
	Q9NZJ7
	Q791T5
	NM_001271641; NM_014341
	NM_019880; NM_001347335; NM_001357762; NM_001357763
	NP_001258570; NP_055156
	NP_001334264; NP_063933; NP_001344691; NP_001344692
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial carrier homolog 1 (MTCH1), also referred to as presenilin 1-associated protein (PSAP), is a protein that in humans is encoded by the MTCH1 gene on chromosome 6. MTCH1 is a proapoptotic mitochondrial protein potentially involved in Alzheimer's disease (AD).