MTDH

MTDH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4QMG
Identifiers
Aliases	MTDH, 3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3, metadherin
External IDs	OMIM: 610323; MGI: 1914404; HomoloGene: 12089; GeneCards: MTDH; OMA:MTDH - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	97,730,260 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	34,145,770 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; secondary oocyte; ; pylorus; ; sural nerve; ; nipple; ; corpus callosum; ; cardia; ; bone marrow cells; ; inferior ganglion of vagus nerve; ; decidua;
	Top expressed in
	otic placode; ; saccule; ; genital tubercle; ; spermatid; ; tail of embryo; ; muscle of thigh; ; triceps brachii muscle; ; ankle; ; neural layer of retina; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; NF-kappaB binding; protein binding; double-stranded RNA binding; RNA binding;
Cellular component	cytoplasm; integral component of membrane; nuclear body; nuclear membrane; endoplasmic reticulum membrane; membrane; bicellular tight junction; intercellular canaliculus; cell junction; apical plasma membrane; endoplasmic reticulum; perinuclear region of cytoplasm; nucleus; fibrillar center; nucleolus;
Biological process	positive regulation of protein kinase B signaling; positive regulation of autophagy; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; positive regulation of angiogenesis; positive regulation of NF-kappaB transcription factor activity; bicellular tight junction assembly; positive regulation of I-kappaB kinase/NF-kappaB signaling; lipopolysaccharide-mediated signaling pathway; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	92140
	67154
	ENSG00000147649
	ENSMUSG00000022255
	Q86UE4
	Q80WJ7
	NM_178812; NM_001363136; NM_001363137; NM_001363138; NM_001363139
	NM_026002; NM_001357925; NM_001357926
	NP_848927; NP_001350065; NP_001350066; NP_001350067; NP_001350068
	NP_080278; NP_001344854; NP_001344855
	Wikidata
View/Edit Human	View/Edit Mouse

Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene.