MTHFD1

MTHFD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A4I, 1DIA, 1DIB, 1DIG
Identifiers
Aliases	MTHFD1, MTHFC, MTHFD, C1-THF-Synthase, methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1, CIMAH
External IDs	OMIM: 172460; MGI: 1342005; HomoloGene: 55940; GeneCards: MTHFD1; OMA:MTHFD1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	76,366,577 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gastrocnemius muscle; ; Achilles tendon; ; adipose tissue; ; ganglionic eminence; ; subcutaneous adipose tissue; ; caudate nucleus; ; nucleus accumbens; ; right coronary artery; ; kidney;
	Top expressed in
	Paneth cell; ; primitive streak; ; right lobe of liver; ; left lobe of liver; ; right kidney; ; epiblast; ; Epithelium of choroid plexus; ; human kidney; ; left lung; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; methylenetetrahydrofolate dehydrogenase (NADP+) activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; ligase activity; methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity]; catalytic activity; oxidoreductase activity; ATP binding; hydrolase activity; protein binding; formate-tetrahydrofolate ligase activity; methenyltetrahydrofolate cyclohydrolase activity;
Cellular component	membrane; mitochondrion; extracellular exosome; cytoplasm; cytosol;
Biological process	purine nucleotide biosynthetic process; transsulfuration; neutrophil homeostasis; one-carbon metabolic process; serine family amino acid metabolic process; embryonic neurocranium morphogenesis; tetrahydrofolate interconversion; histidine biosynthetic process; cellular amino acid biosynthetic process; somite development; serine family amino acid biosynthetic process; methionine biosynthetic process; heart development; methionine metabolic process; neural tube closure; folic acid metabolic process; embryonic viscerocranium morphogenesis; metabolism; purine nucleobase biosynthetic process; 10-formyltetrahydrofolate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4522
	108156
	n/a
	ENSMUSG00000021048
	P11586
	Q922D8
	NM_005956; NM_001364837
	NM_138745
	NP_005947; NP_001351766
	NP_620084
	Wikidata
View/Edit Human	View/Edit Mouse

Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (MTHFD1) is a gene located in humans on chromosome 14 that encodes a protein, C-1-tetrahydrofolate synthase, cytoplasmic also known as C1-THF synthase, with three distinct enzymatic activities.