MTHFD2

MTHFD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZN4
Identifiers
Aliases	MTHFD2, NMDMC, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
External IDs	OMIM: 604887; MGI: 1338850; HomoloGene: 21321; GeneCards: MTHFD2; OMA:MTHFD2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,217,565 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,302,890 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; ascending aorta; ; gonad; ; left coronary artery; ; right coronary artery; ; stromal cell of endometrium; ; tibia;
	Top expressed in
	lacrimal gland; ; seminal vesicula; ; Ileal epithelium; ; zygote; ; calvaria; ; secondary oocyte; ; primary oocyte; ; primitive streak; ; Paneth cell; ; salivary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; catalytic activity; hydrolase activity; methenyltetrahydrofolate cyclohydrolase activity; magnesium ion binding; methylenetetrahydrofolate dehydrogenase (NAD+) activity; methylenetetrahydrofolate dehydrogenase (NADP+) activity; phosphate ion binding;
Cellular component	mitochondrion; cytosol; mitochondrial matrix; extracellular space;
Biological process	metabolism; one-carbon metabolic process; tetrahydrofolate metabolic process; folic acid metabolic process; tetrahydrofolate interconversion;
	Sources:Amigo / QuickGO
Orthologs
	10797
	17768
	ENSG00000065911
	ENSMUSG00000005667
	P13995
	P18155
	NM_001040409; NM_006636
	NM_008638
	NP_006627
	NP_032664
	Wikidata
View/Edit Human	View/Edit Mouse

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial is an enzyme that in humans is encoded by the MTHFD2 gene.

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in multiple transcripts encoding different isoforms. This gene has a pseudogene on chromosome 7.