Mitochondrial translational release factor 1

MTRF1
Identifiers
Aliases	MTRF1, MRF1, MTTRF1, RF1, mitochondrial translational release factor 1, mitochondrial translation release factor 1
External IDs	OMIM: 604601; MGI: 2384815; HomoloGene: 20903; GeneCards: MTRF1; OMA:MTRF1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	41,263,577 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	79,661,027 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; rectum; ; right adrenal gland; ; right adrenal cortex; ; gallbladder; ; left adrenal gland; ; granulocyte; ; testicle; ; left adrenal cortex; ; body of stomach;
	Top expressed in
	left ventricle; ; interventricular septum; ; quadriceps femoris muscle; ; primary oocyte; ; muscle tissue; ; proximal tubule; ; muscle of thigh; ; skeletal muscle tissue; ; right kidney; ; ovary;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation release factor activity; translation release factor activity, codon specific; ribosome binding;
Cellular component	mitochondrion; cytoplasm;
Biological process	translational termination; regulation of translational termination; protein biosynthesis; mitochondrial translational termination;
	Sources:Amigo / QuickGO
Orthologs
	9617
	211253
	ENSG00000120662
	ENSMUSG00000022022
	O75570; Q8N6Z2
	Q8K126
	NM_004294; NM_001354073; NM_001354074; NM_001354076
	NM_145960
	NP_004285; NP_001341002; NP_001341003; NP_001341005
	NP_666072
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.

The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.