MTRF1L

MTRF1L
Identifiers
Aliases	MTRF1L, HMRF1L, MRF1L, mtRF1a, mitochondrial translational release factor 1 like, mitochondrial translation release factor 1 like, Mitochondrial translational release factor 1-like
External IDs	OMIM: 613542; MGI: 1918830; HomoloGene: 5905; GeneCards: MTRF1L; OMA:MTRF1L - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	153,002,709 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	5,773,910 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; endothelial cell; ; buccal mucosa cell; ; pancreatic ductal cell; ; internal globus pallidus; ; tibialis anterior muscle; ; deltoid muscle; ; body of tongue; ; tendon of biceps brachii; ; pericardium;
	Top expressed in
	tail of embryo; ; genital tubercle; ; otic vesicle; ; Paneth cell; ; medullary collecting duct; ; otolith organ; ; utricle; ; migratory enteric neural crest cell; ; renal corpuscle; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation release factor activity; translation release factor activity, codon specific; ribosome binding;
Cellular component	mitochondrial matrix; mitochondrion; cytoplasm;
Biological process	translational termination; protein biosynthesis; mitochondrial translational termination;
	Sources:Amigo / QuickGO
Orthologs
	54516
	108853
	ENSG00000112031
	ENSMUSG00000019774
	Q9UGC7
	Q8BJU9
NM_001114184; NM_001301047; NM_001301870; NM_001301871; NM_001301872;
	NM_019041
	NM_175374
NP_001107656; NP_001287976; NP_001288799; NP_001288800; NP_001288801;
	NP_061914
	NP_780583
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial translational release factor 1-like is a protein that in humans is encoded by the MTRF1L gene.

Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 [PubMed 18429816]).[supplied by OMIM].