Mucin 5B

MUC5B
Identifiers
Aliases	MUC5B, MG1, MUC-5B, MUC5, MUC9, mucin 5B, oligomeric mucus/gel-forming
External IDs	OMIM: 600770; MGI: 1921430; HomoloGene: 136756; GeneCards: MUC5B; OMA:MUC5B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,262,172 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,426,821 bp
RNA expression pattern
	Top expressed in
	trachea; ; gallbladder; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; bronchus; ; epithelium of bronchus; ; bronchial epithelial cell; ; tendon of biceps brachii; ; minor salivary glands; ; mucosa of sigmoid colon;
	Top expressed in
	trachea; ; olfactory epithelium; ; right lung; ; cervix; ; right lung lobe; ; conjunctival fornix; ; cochlea; ; carotid body; ; left lung; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi lumen; extracellular region; extracellular exosome; intracellular membrane-bounded organelle; plasma membrane; extracellular space;
Biological process	O-glycan processing; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	727897
	74180
	ENSG00000117983
	ENSMUSG00000066108
	Q9HC84
	n/a
	NM_002458
	NM_028801
	NP_002449
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene and by the Muc5b gene in the mouse. It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases, such as COPD, chronic rhinosinusitis (CRS), and H. pylori-associated gastric disease, the gene has been found to be upregulated, and this may be related to the pathogenesis of these conditions.