MUS81

MUS81
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MC3, 4P0P, 4P0Q, 4P0R, 4P0S
Identifiers
Aliases	MUS81, SLX3, MUS81 structure-specific endonuclease subunit
External IDs	OMIM: 606591; MGI: 1918961; HomoloGene: 5725; GeneCards: MUS81; OMA:MUS81 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,867,653 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,538,430 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; left uterine tube; ; muscle layer of sigmoid colon; ; granulocyte; ; mucosa of transverse colon; ; right ovary; ; canal of the cervix; ; right coronary artery; ; apex of heart; ; left coronary artery;
	Top expressed in
	muscle of thigh; ; primary oocyte; ; cerebellar cortex; ; otic vesicle; ; spermatocyte; ; saccule; ; granulocyte; ; thymus; ; superior frontal gyrus; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nuclease activity; endonuclease activity; protein binding; 3'-flap endonuclease activity; metal ion binding; hydrolase activity; endodeoxyribonuclease activity; crossover junction endodeoxyribonuclease activity;
Cellular component	nucleoplasm; nucleus; nucleolus; Holliday junction resolvase complex;
Biological process	DNA recombination; interstrand cross-link repair; DNA catabolic process, endonucleolytic; cellular response to DNA damage stimulus; response to intra-S DNA damage checkpoint signaling; DNA repair; resolution of meiotic recombination intermediates; double-strand break repair via break-induced replication; mitotic G2 DNA damage checkpoint signaling; replication fork processing; mitotic intra-S DNA damage checkpoint signaling; DNA metabolic process; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	80198
	71711
	ENSG00000172732
	ENSMUSG00000024906
	Q96NY9
	Q91ZJ0
	NM_025128; NM_001350283
	NM_027877
	NP_079404; NP_001337212
	NP_082153
	Wikidata
View/Edit Human	View/Edit Mouse

Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene.

In mammalian somatic cells, MUS81 and another structure specific DNA endonuclease, XPF (ERCC4), play overlapping and essential roles in completion of homologous recombination. The significant overlap in function between these enzymes is most likely related to processing joint molecules such as D-loops and nicked Holliday junctions.