MUTYH

MUTYH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X51, 3N5N
Identifiers
Aliases	MUTYH, MYH, mutY DNA glycosylase, mutY homolog (E. coli)
External IDs	OMIM: 604933; MGI: 1917853; HomoloGene: 8156; GeneCards: MUTYH; OMA:MUTYH - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	45,340,893 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	116,676,637 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; mucosa of transverse colon; ; granulocyte; ; right lobe of thyroid gland; ; right uterine tube; ; left lobe of thyroid gland; ; spleen; ; tibial nerve; ; pituitary gland;
	Top expressed in
	tail of embryo; ; embryo; ; epiblast; ; embryo; ; morula; ; ventricular zone; ; blastocyst; ; secondary oocyte; ; genital tubercle; ; ectoderm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MutSalpha complex binding; metal ion binding; hydrolase activity, acting on glycosyl bonds; hydrolase activity; catalytic activity; iron-sulfur cluster binding; MutLalpha complex binding; 4 iron, 4 sulfur cluster binding; MutLbeta complex binding; MutSbeta complex binding; protein binding; DNA N-glycosylase activity; DNA binding; purine-specific mismatch base pair DNA N-glycosylase activity; oxidized purine DNA binding; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; adenine/guanine mispair binding;
Cellular component	nucleoplasm; mitochondrion; nucleus;
Biological process	DNA repair; metabolism; depurination; cellular response to DNA damage stimulus; DNA mismatch repair; base-excision repair;
	Sources:Amigo / QuickGO
Orthologs
	4595
	70603
	ENSG00000132781
	ENSMUSG00000028687
	Q9UIF7
	Q99P21
NM_001048171; NM_001048172; NM_001048173; NM_001048174; NM_001128425;
	NM_001293190; NM_001293191; NM_001293192; NM_001293195; NM_001293196; NM_012222; NM_001350650; NM_001350651
	NM_001159581; NM_133250; NM_001316747
NP_001041636; NP_001041637; NP_001041638; NP_001041639; NP_001121897;
	NP_001280119; NP_001280120; NP_001280121; NP_001280124; NP_001280125; NP_036354; NP_001337579; NP_001337580; NP_001280121.1; NP_001280125.1
	NP_001153053; NP_001303676; NP_573513
	Wikidata
View/Edit Human	View/Edit Mouse

MUTYH (mutY DNA glycosylase) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase. It is involved in oxidative DNA damage repair and is part of the base excision repair pathway. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a common form of oxidative DNA damage.

The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.