Mevalonate kinase

MVK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R3V
Identifiers
Aliases	MVK, LRBP, MK, MVLK, POROK3, mevalonate kinase
External IDs	OMIM: 251170, 260920, 610377, 175900; MGI: 107624; HomoloGene: 372; GeneCards: MVK; OMA:MVK - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	109,598,125 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	114,598,652 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; C1 segment; ; pancreatic ductal cell; ; skin of leg; ; skin of abdomen; ; left testis; ; right testis; ; olfactory zone of nasal mucosa; ; right adrenal cortex; ; left adrenal cortex;
	Top expressed in
	lip; ; tongue; ; yolk sac; ; Meckel's cartilage; ; neural tube; ; ventricular zone; ; esophagus; ; Ileal epithelium; ; entorhinal cortex; ; choroid plexus of fourth ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; kinase activity; protein binding; mevalonate kinase activity; magnesium ion binding; ATP binding; identical protein binding; metal ion binding;
Cellular component	cytoplasm; cytosol; peroxisome;
Biological process	steroid metabolic process; sterol biosynthetic process; phosphorylation; lipid metabolism; cholesterol metabolic process; isoprenoid biosynthetic process; cholesterol biosynthetic process; negative regulation of inflammatory response; steroid biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; regulation of cholesterol biosynthetic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	4598
	17855
	ENSG00000110921
	ENSMUSG00000041939
	Q03426
	Q9R008
	NM_000431; NM_001114185; NM_001301182
	NM_023556; NM_001306205
	NP_000422; NP_001107657; NP_001288111
	NP_001293134; NP_076045
	Wikidata
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NCBI	proteins

Mevalonate Kinase
Mevalonate Kinase
	Crystallographic structure of mevalonate kinase from Staphylococcus aureus.
Identifiers
EC no.	2.7.1.36
CAS no.	9026-52-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Mevalonate kinase is an enzyme (specifically a kinase) that in humans is encoded by the MVK gene. Mevalonate kinases are found in a wide variety of organisms from bacteria to mammals. This enzyme catalyzes the following reaction:

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