MX1

MX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LJB, 3SZR, 3ZYS, 4P4S, 4P4T, 4P4U
Identifiers
Aliases	MX1, IFI-78K, IFI78, MX, MxA, MX dynamin like GTPase 1, lncMX1-215
External IDs	OMIM: 147150; MGI: 97244; HomoloGene: 1844; GeneCards: MX1; OMA:MX1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	41,470,071 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	97,362,100 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; spinal ganglia; ; nasal epithelium; ; palpebral conjunctiva; ; monocyte; ; decidua; ; olfactory zone of nasal mucosa; ; granulocyte; ; spleen; ; human penis;
	Top expressed in
	embryo; ; surface ectoderm; ; duodenum; ; thymus; ; choroid plexus of fourth ventricle; ; yolk sac; ; muscle of thigh; ; liver; ; islet of Langerhans; ; perirhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity; microtubule binding; identical protein binding;
Cellular component	cytoplasm; cytosol; nuclear membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; nucleus; mitochondrial membranes;
Biological process	defense response; immune system process; response to virus; type I interferon signaling pathway; innate immune response; signal transduction; apoptotic process; response to type I interferon; negative regulation of viral genome replication; mitochondrial fission; dynamin family protein polymerization involved in mitochondrial fission; membrane fusion; defense response to virus;
	Sources:Amigo / QuickGO
Orthologs
	4599
	17858
	ENSG00000157601
	ENSMUSG00000023341
	P20591
	Q9WVP9
	NM_001144925; NM_001178046; NM_001282920; NM_002462
	NM_013606
	NP_001138397; NP_001171517; NP_001269849; NP_002453
	NP_038634
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.

In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Furthermore, the human orthologue MxA is a major host determinant for influenza viruses of animal origin. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.