MXD1

MXD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E91, 1G1E, 1NLW, 1PD7, 1S5Q
Identifiers
Aliases	MXD1, BHLHC58, MAD, MAD1, MAX dimerization protein 1
External IDs	OMIM: 600021; MGI: 96908; HomoloGene: 1767; GeneCards: MXD1; OMA:MXD1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	69,942,945 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	86,646,143 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; mucosa of pharynx; ; oocyte; ; secondary oocyte; ; amniotic fluid; ; blood; ; oral cavity; ; jejunal mucosa; ; mucosa of colon; ; mucosa of sigmoid colon;
	Top expressed in
	granulocyte; ; left colon; ; blood; ; retinal pigment epithelium; ; duodenum; ; ciliary body; ; secondary oocyte; ; epithelium of stomach; ; jejunum; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; transcription coregulator activity; protein dimerization activity; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; mitochondrion; cytosol;
Biological process	multicellular organism development; cell population proliferation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	4084
	17119
	ENSG00000059728
	ENSMUSG00000001156
	Q05195
	P50538
	NM_002357; NM_001202513; NM_001202514
	NM_010751
	NP_001189442; NP_001189443; NP_002348
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

MAD protein is a protein that in humans is encoded by the MXD1 gene.

MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.