Myosin binding protein C, cardiac

MYBPC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GXE, 2AVG, 2K1M, 2MQ0, 2MQ3, 2V6H, 3CX2, 1PD6
Identifiers
Aliases	MYBPC3, CMD1MM, CMH4, FHC, LVNC10, MYBP-C, Myosin binding protein C, cardiac, cMyBP-C, myosin binding protein C3
External IDs	OMIM: 600958; MGI: 102844; HomoloGene: 215; GeneCards: MYBPC3; OMA:MYBPC3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,352,702 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	90,966,861 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right auricle of heart; ; myocardium of left ventricle; ; right ventricle; ; cardiac muscle tissue of right atrium; ; vena cava; ; testicle; ; blood; ; pericardium; ; gonad;
	Top expressed in
	myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; cardiac muscle tissue of left ventricle; ; atrium; ; interventricular septum; ; endocardial cushion; ; atrioventricular valve; ; semi-lunar valve; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	myosin binding; titin binding; metal ion binding; myosin heavy chain binding; protein binding; identical protein binding; actin binding; ATPase activator activity; structural constituent of muscle; actin filament binding; muscle alpha-actinin binding; structural molecule activity conferring elasticity;
Cellular component	cytosol; C zone; sarcomere; striated muscle myosin thick filament; myosin filament; A band; Z discdkac; M band; cardiac myofibril; striated muscle thin filament;
Biological process	regulation of muscle filament sliding; positive regulation of ATP-dependent activity; cardiac muscle contraction; heart morphogenesis; ventricular cardiac muscle tissue morphogenesis; regulation of striated muscle contraction; cell adhesion; muscle filament sliding; striated muscle contraction; actin filament organization; sarcomere organization; striated muscle myosin thick filament assembly; muscle contraction; skeletal muscle thin filament assembly; skeletal muscle myosin thick filament assembly; cardiac myofibril assembly; cardiac muscle tissue morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4607
	17868
	ENSG00000134571
	ENSMUSG00000002100
	Q14896
	O70468
	NM_000256
	NM_008653
	NP_000247; NP_000247.2
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the MYBPC3 gene. This isoform is expressed exclusively in heart muscle during human and mouse development, and is distinct from those expressed in slow skeletal muscle (MYBPC1) and fast skeletal muscle (MYBPC2).