MYH1

MYH1
Identifiers
Aliases	MYH1, HEL71, MYHSA1, MYHa, MyHC-2X/D, MyHC-2x, myosin, heavy chain 1, skeletal muscle, adult, myosin heavy chain 1
External IDs	OMIM: 160730; MGI: 1339711; HomoloGene: 133718; GeneCards: MYH1; OMA:MYH1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	10,518,542 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	67,115,401 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; thoracic diaphragm; ; gastrocnemius muscle; ; deltoid muscle; ; triceps brachii muscle; ; larynx;
	Top expressed in
	masseter muscle; ; digastric muscle; ; intercostal muscle; ; extraocular muscle; ; ankle; ; temporal muscle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; actin binding; cytoskeletal motor activity; protein binding; ATP binding; calmodulin binding; actin filament binding; microtubule motor activity; microtubule binding;
Cellular component	cytoplasm; myosin filament; cytoplasmic ribonucleoprotein granule; myofibril; myosin complex; muscle myosin complex; intercalated disc; A band;
Biological process	microtubule-based movement; muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	4619
	17879
	ENSG00000109061
	ENSMUSG00000056328
	P12882
	Q5SX40
	NM_005963
	NM_030679
	NP_005954
	NP_109604
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene. This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail.