MYH10

MYH10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PD3
Identifiers
Aliases	MYH10, NMMHC-IIB, NMMHCB, myosin, heavy chain 10, non-muscle, myosin heavy chain 10
External IDs	OMIM: 160776; MGI: 1930780; HomoloGene: 55941; GeneCards: MYH10; OMA:MYH10 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,631,376 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	68,707,458 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; right coronary artery; ; ascending aorta; ; Descending thoracic aorta; ; middle temporal gyrus; ; Brodmann area 23; ; vena cava; ; lateral nuclear group of thalamus; ; visceral pleura; ; endothelial cell;
	Top expressed in
	genital tubercle; ; ventricular zone; ; ganglionic eminence; ; tail of embryo; ; cerebellar cortex; ; superior frontal gyrus; ; yolk sac; ; dentate gyrus of hippocampal formation granule cell; ; bone marrow; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ADP binding; calmodulin binding; actin filament binding; microfilament motor activity; protein binding; actin binding; cytoskeletal motor activity; ATP binding; ATPase activity; RNA stem-loop binding; mRNA 5'-UTR binding; microtubule motor activity; microtubule binding;
Cellular component	cytosol; myosin II filament; cell projection; midbody; cleavage furrow; actomyosin; extracellular exosome; nucleus; myosin complex; lamellipodium; stress fiber; cytoplasm; cell cortex; myosin II complex; spindle; polysome; plasma membrane; brush border; axon; growth cone; neuromuscular junction; neuron projection; soma; dendritic spine; glutamatergic synapse;
Biological process	actomyosin structure organization; actin filament-based movement; cell adhesion; regulation of cell shape; mitotic cytokinesis; in utero embryonic development; neuron migration; plasma membrane repair; cardiac septum development; exocytosis; substrate-dependent cell migration, cell extension; nuclear migration; axonogenesis; axon guidance; brain development; heart development; adult heart development; cell population proliferation; fourth ventricle development; lateral ventricle development; third ventricle development; cerebellar Purkinje cell layer development; actin cytoskeleton organization; myofibril assembly; neuron projection development; aorta development; positive regulation of protein secretion; neuromuscular process controlling balance; cardiac myofibril assembly; ventricular cardiac muscle cell development; retina development in camera-type eye; coronary vasculature development; modification of postsynaptic actin cytoskeleton; postsynaptic actin cytoskeleton organization; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	4628
	77579
	ENSG00000133026
	ENSMUSG00000020900
	P35580
	Q61879
	NM_001256012; NM_001256095; NM_005964; NM_001375266
	NM_175260
	NP_001242941; NP_001243024; NP_005955; NP_001362195
	NP_780469
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-10 also known as myosin heavy chain 10 or non-muscle myosin IIB (NM-IIB) is a protein that in humans is encoded by the MYH10 gene. Non-muscle myosins are expressed in a wide variety of tissues, but NM-IIB is the only non-muscle myosin II isoform expressed in cardiac muscle, where it localizes to adherens junctions within intercalated discs. NM-IIB is essential for normal development of cardiac muscle and for integrity of intercalated discs. Mutations in MYH10 have been identified in patients with left atrial enlargement.