MYH6

MYH6
Identifiers
Aliases	MYH6, ASD3, CMD1EE, CMH14, MYHC, MYHCA, SSS3, alpha-MHC, myosin, heavy chain 6, cardiac muscle, alpha, myosin heavy chain 6
External IDs	OMIM: 160710; MGI: 97255; HomoloGene: 124414; GeneCards: MYH6; OMA:MYH6 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,408,273 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,204,384 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; vena cava; ; right auricle of heart; ; right ventricle; ; myocardium of left ventricle; ; apex of heart; ; glutes; ; thoracic diaphragm; ; triceps brachii muscle; ; gastrocnemius muscle;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; atrium; ; interventricular septum; ; atrioventricular junction; ; atrioventricular valve; ; right ventricle; ; aortic valve; ; endocardial cushion; ; lung; ; right lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; calmodulin binding; ATPase activity; actin binding; cytoskeletal motor activity; ATP binding; protein kinase binding; myosin phosphatase activity; actin filament binding; microfilament motor activity; microtubule motor activity; microtubule binding;
Cellular component	cytoplasm; cytosol; sarcomere; myofibril; myosin filament; muscle myosin complex; myosin complex; stress fiber; Z discdkac;
Biological process	muscle contraction; ventricular cardiac muscle tissue morphogenesis; ATP metabolic process; muscle filament sliding; atrial cardiac muscle tissue morphogenesis; protein dephosphorylation; in utero embryonic development; regulation of the force of heart contraction; regulation of heart rate; striated muscle contraction; adult heart development; visceral muscle development; regulation of heart contraction; regulation of blood pressure; cardiac muscle hypertrophy in response to stress; actin filament-based movement; myofibril assembly; BMP signaling pathway; regulation of ATP-dependent activity; sarcomere organization; cardiac muscle contraction; canonical Wnt signaling pathway; regulation of heart growth; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	4624
	17888
	ENSG00000197616
	ENSMUSG00000040752
	P13533
	Q02566
	NM_002471
	NM_001164171; NM_010856
	NP_002462
	NP_001157643; NP_034986
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin heavy chain, α isoform (MHC-α) is a protein that in humans is encoded by the MYH6 gene. This isoform is distinct from the ventricular/slow myosin heavy chain isoform, MYH7, referred to as MHC-β. MHC-α isoform is expressed predominantly in human cardiac atria, exhibiting only minor expression in human cardiac ventricles. It is the major protein comprising the cardiac muscle thick filament, and functions in cardiac muscle contraction. Mutations in MYH6 have been associated with late-onset hypertrophic cardiomyopathy, atrial septal defects and sick sinus syndrome.