MYH9

MYH9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LNK, 3ZWH, 4CFQ, 4CFR, 4ETO
Identifiers
Aliases	MYH9, BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA, myosin, heavy chain 9, non-muscle, myosin heavy chain 9, MATINS
External IDs	OMIM: 160775; MGI: 107717; HomoloGene: 129835; GeneCards: MYH9; OMA:MYH9 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	36,388,010 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	77,726,375 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; stromal cell of endometrium; ; Descending thoracic aorta; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; body of uterus; ; epithelium of colon; ; right lung; ; left coronary artery;
	Top expressed in
	aortic valve; ; ascending aorta; ; right lung lobe; ; tibiofemoral joint; ; external carotid artery; ; internal carotid artery; ; granulocyte; ; Gonadal ridge; ; medullary collecting duct; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; nucleotide binding; microfilament motor activity; protein binding; ADP binding; protein-membrane adaptor activity; calmodulin binding; ATPase activity; protein domain specific binding; actin binding; cytoskeletal motor activity; ATP binding; RNA binding; cadherin binding; actin filament binding; microtubule motor activity; microtubule binding;
Cellular component	myosin II filament; cell cortex; brush border; actomyosin; myosin complex; integrin complex; ruffle; nucleus; cell leading edge; actomyosin contractile ring; cytoskeleton; cleavage furrow; cortical cytoskeleton; actin cytoskeleton; spindle; membrane; COP9 signalosome; extracellular exosome; neuromuscular junction; cytoplasm; cytosol; focal adhesion; plasma membrane; stress fiber; uropod; immunological synapse; myosin II complex; extracellular matrix;
Biological process	in utero embryonic development; protein transport; monocyte differentiation; uropod organization; cell adhesion; cell morphogenesis involved in differentiation; platelet formation; leukocyte migration; establishment of meiotic spindle localization; blood vessel endothelial cell migration; establishment of T cell polarity; myoblast fusion; membrane protein ectodomain proteolysis; actomyosin structure organization; angiogenesis; integrin-mediated signaling pathway; actin cytoskeleton reorganization; regulation of cell shape; actin filament-based movement; platelet aggregation; meiotic spindle organization; phagocytosis, engulfment; negative regulation of actin filament severing; positive regulation of protein processing in phagocytic vesicle; cytokinetic process; cell-cell adhesion; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	4627
	17886
	ENSG00000100345
	ENSMUSG00000022443
	P35579; Q5BKV1
	Q8VDD5
	NM_002473
	NM_022410
	NP_002464; NP_002464.1
	NP_071855
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-9 also known as myosin, heavy chain 9, non-muscle or non-muscle myosin heavy chain IIa (NMMHC-IIA) is a protein which in humans is encoded by the MYH9 gene.

Non-muscle myosin IIA (NM IIA) is expressed in most cells and tissues where it participates in a variety of processes requiring contractile force, such as cytokinesis, cell migration, polarization and adhesion, maintenance of cell shape, and signal transduction. Myosin IIs are motor proteins that are part of a superfamily composed of more than 30 classes. Class II myosins include muscle and non-muscle myosins that are organized as hexameric molecules consisting of two heavy chains (230 kDa), two regulatory light chains (20 KDa) controlling the myosin activity, and two essential light chains (17 kDa), which stabilize the heavy chain structure.