MYL4

MYL4
Identifiers
Aliases	MYL4, ALC1, AMLC, GT1, PRO1957, myosin light chain 4
External IDs	OMIM: 160770; MGI: 97267; HomoloGene: 20558; GeneCards: MYL4; OMA:MYL4 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,223,679 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	104,595,753 bp
RNA expression pattern
	Top expressed in
	right auricle of heart; ; cardiac muscle tissue of right atrium; ; apex of heart; ; vena cava; ; right ventricle; ; testicle; ; trabecular bone; ; left ventricle; ; blood; ; bone marrow;
	Top expressed in
	atrium; ; endocardial cushion; ; atrioventricular valve; ; aortic valve; ; internal carotid artery; ; human fetus; ; interventricular septum; ; right lung; ; right lung lobe; ; fossa;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; actin filament binding; actin monomer binding; myosin II heavy chain binding;
Cellular component	cytosol; A band; myosin complex;
Biological process	positive regulation of ATP-dependent activity; cardiac muscle contraction; regulation of the force of heart contraction; muscle filament sliding;
	Sources:Amigo / QuickGO
Orthologs
	4635
	17896
	ENSG00000198336
	ENSMUSG00000061086
	P12829
	P09541
	NM_001002841; NM_002476
	NM_010858; NM_001355754; NM_001355755
	NP_001002841; NP_002467
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases.