MYL7

MYL7
Identifiers
Aliases	MYL7, MYL2A, MYLC2A, myosin light chain 7
External IDs	OMIM: 613993; MGI: 107495; HomoloGene: 23290; GeneCards: MYL7; OMA:MYL7 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,141,332 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,848,782 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; right auricle of heart; ; apex of heart; ; vena cava; ; left ventricle; ; right ventricle; ; myocardium of left ventricle; ; anterior pituitary; ; gonad; ; right hemisphere of cerebellum;
	Top expressed in
	atrium; ; atrioventricular valve; ; endocardial cushion; ; aortic valve; ; interventricular septum; ; right atrium; ; right lung; ; left atrium; ; right lung lobe; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; metal ion binding;
Cellular component	cytosol; dendritic spine; A band; myosin complex;
Biological process	muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	58498
	17898
	ENSG00000106631
	ENSMUSG00000020469
	Q01449
	Q9QVP4
	NM_021223
	NM_022879
	NP_067046
	NP_075017
	Wikidata
View/Edit Human	View/Edit Mouse

Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans is encoded by the MYL7 gene. ALC-2 expression is restricted to cardiac muscle atria in healthy individuals, where it functions to modulate cardiac development and contractility. In human diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and others, ALC-2 expression is altered.