MYO1G

MYO1G
Identifiers
Aliases	MYO1G, HA2, HLA-HA2, MHAG, myosin IG
External IDs	OMIM: 600642; MGI: 1927091; HomoloGene: 27996; GeneCards: MYO1G; OMA:MYO1G - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,979,088 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,470,965 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; thymus; ; blood; ; lymph node; ; cecum; ; appendix; ; spleen; ; pylorus; ; bone marrow cells;
	Top expressed in
	granulocyte; ; lymph node; ; mesenteric lymph nodes; ; spleen; ; tibiofemoral joint; ; thymus; ; bone marrow; ; blood; ; stroma of bone marrow; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; calmodulin binding; phosphatidylinositol-3,4-bisphosphate binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; cytoskeletal motor activity; ATP binding; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding;
Cellular component	cell projection; membrane; filopodium; plasma membrane; microvillus; phagocytic cup; extracellular exosome; leading edge membrane; myosin complex; lamellipodium;
Biological process	T cell migration; T cell mediated immunity; adaptive immune response; Fc-gamma receptor signaling pathway involved in phagocytosis; cell gliding; immune system process; cell-substrate adhesion; phagocytosis; exocytosis; T cell meandering migration;
	Sources:Amigo / QuickGO
Orthologs
	64005
	246177
	ENSG00000136286
	ENSMUSG00000020437
	B0I1T2
	Q5SUA5
	NM_033054
	NM_178440
	NP_149043
	NP_848534
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene. MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain. MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.