Unconventional myosin-Va

MYO5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4J5L, 4LX1, 4LX2, 4LLI, 4D07
Identifiers
Aliases	MYO5A, GS1, MYH12, MYO5, MYR12, myosin VA
External IDs	OMIM: 160777; MGI: 105976; HomoloGene: 20100; GeneCards: MYO5A; OMA:MYO5A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	52,529,132 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	75,130,970 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; endothelial cell; ; pars compacta; ; Brodmann area 23; ; pars reticulata; ; parietal lobe; ; postcentral gyrus; ; Pons; ; superior frontal gyrus; ; entorhinal cortex;
	Top expressed in
	medial geniculate nucleus; ; pontine nuclei; ; medial dorsal nucleus; ; ventral tegmental area; ; lateral geniculate nucleus; ; stroma of bone marrow; ; subiculum; ; dorsal tegmental nucleus; ; habenula; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; nucleotide binding; calmodulin binding; microfilament motor activity; actin binding; cytoskeletal motor activity; ATP binding; RNA binding; disordered domain specific binding; identical protein binding; protein binding; actin filament binding;
Cellular component	cytoplasm; recycling endosome; vesicle; cytosol; late endosome; Golgi apparatus; membrane; growth cone; ruffle; melanosome; insulin-responsive compartment; photoreceptor outer segment; peroxisome; secretory granule; microtubule plus-end; filopodium tip; soma; early endosome; endoplasmic reticulum; actin filament; neuron projection; lysosome; actomyosin; intermediate filament; extracellular exosome; myosin complex; unconventional myosin complex; smooth endoplasmic reticulum; postsynapse; glutamatergic synapse;
Biological process	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; melanin biosynthetic process; synapse organization; insulin secretion; secretory granule localization; melanosome localization; actin filament-based movement; post-Golgi vesicle-mediated transport; odontogenesis; endoplasmic reticulum localization; melanin metabolic process; regulation of Golgi organization; long-chain fatty acid biosynthetic process; melanosome transport; cellular response to insulin stimulus; vesicle transport along actin filament; protein transport; developmental pigmentation; myelination; pigmentation; protein localization to plasma membrane; melanocyte differentiation; locomotion involved in locomotory behavior; vesicle-mediated transport; visual perception; exocytosis; chemical synaptic transmission; hair follicle maturation; transport; establishment of endoplasmic reticulum localization to postsynapse; regulation of postsynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	4644
	17918
	ENSG00000197535
	ENSMUSG00000034593
	Q9Y4I1
	Q99104
	NM_000259; NM_001142495; NM_001382347; NM_001382348; NM_001382349
	NM_010864
	NP_000250; NP_001135967; NP_001369276; NP_001369277; NP_001369278
	NP_034994
	Wikidata
View/Edit Human	View/Edit Mouse

Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments. In humans it is coded for by the MYO5A gene.