MYO5B

MYO5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4J5M, 4LNZ, 4LWZ, 4LX0
Identifiers
Aliases	MYO5B, myosin VB, MVID1, DIAR2, PFIC10
External IDs	OMIM: 606540; MGI: 106598; HomoloGene: 49481; GeneCards: MYO5B; OMA:MYO5B - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	50,195,147 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	74,904,564 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; jejunal mucosa; ; pancreatic ductal cell; ; rectum; ; mucosa of transverse colon; ; duodenum; ; islet of Langerhans; ; mucosa of sigmoid colon; ; nasal epithelium; ; palpebral conjunctiva;
	Top expressed in
	primary oocyte; ; dentate gyrus of hippocampal formation granule cell; ; zygote; ; secondary oocyte; ; jejunum; ; ileum; ; epithelium of lens; ; intestinal epithelium; ; epithelium of small intestine; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; calmodulin binding; microfilament motor activity; protein binding; actin binding; cytoskeletal motor activity; ATP binding; actin filament binding;
Cellular component	cytoplasm; recycling endosome; apical cortex; extracellular exosome; cytoplasmic vesicle membrane; myosin complex; protein-containing complex;
Biological process	renal water homeostasis; protein transport; vesicle-mediated transport; transport; endosomal transport;
	Sources:Amigo / QuickGO
Orthologs
	4645
	17919
	ENSG00000167306
	ENSMUSG00000025885
	Q9ULV0
	P21271
	NM_001080467
	NM_008661; NM_201600
	NP_001073936
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans.

Recent evidence suggests that Myosin-Vb is related to the creation of memories by actin-dependent trafficking of AMPA receptor containing recycling endosomes in dendritic spines.

Mutations of MYO5B cause microvillus inclusion disease due to defective trafficking of apical and basolateral proteins.

MYO5B has also been associated with bipolar disorder.