Unconventional myosin-VI

MYO6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N11, 2N13, 2N0Z, 2N10, 2N12
Identifiers
Aliases	MYO6, DFNA22, DFNB37, myosin VI, Myo6-008, Myo6-007
External IDs	OMIM: 600970; MGI: 104785; HomoloGene: 56417; GeneCards: MYO6; OMA:MYO6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	75,919,537 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	80,219,011 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; internal globus pallidus; ; corpus callosum; ; sural nerve; ; external globus pallidus; ; pancreatic ductal cell; ; inferior ganglion of vagus nerve; ; pars reticulata; ; subthalamic nucleus; ; renal medulla;
	Top expressed in
	olfactory epithelium; ; neural layer of retina; ; yolk sac; ; right kidney; ; human kidney; ; utricle; ; epithelium of small intestine; ; ileum; ; Ileal epithelium; ; vestibular sensory epithelium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytoskeletal motor activity; actin filament binding; ATP binding; calmodulin binding; protein binding; minus-end directed microfilament motor activity; ADP binding; actin binding; nucleotide binding; cadherin binding; identical protein binding;
Cellular component	myosin complex; nucleus; intracellular membrane-bounded organelle; cell projection; ruffle membrane; RNA polymerase II, holoenzyme; nucleoplasm; lysosomal membrane; perinuclear region of cytoplasm; clathrin-coated endocytic vesicle; apical part of cell; clathrin-coated vesicle membrane; ruffle; cytosol; extracellular exosome; membrane; clathrin-coated pit; filamentous actin; plasma membrane; nuclear membrane; cytoplasm; cell cortex; microvillus; Golgi apparatus; unconventional myosin complex; endocytic vesicle; cytoplasmic vesicle; actin filament; protein-containing complex; clathrin-coated vesicle; filopodium;
Biological process	intracellular protein transport; actin filament-based movement; regulation of secretion; hearing; positive regulation of transcription by RNA polymerase II; protein transport; endocytosis; DNA damage response, signal transduction by p53 class mediator; transport;
	Sources:Amigo / QuickGO
Orthologs
	4646
	17920
	ENSG00000196586
	ENSMUSG00000033577
	Q9UM54
	Q64331
NM_001300899; NM_004999; NM_001368136; NM_001368137; NM_001368138;
	NM_001368139; NM_001368140; NM_001368865; NM_001368866
	NM_001039546; NM_008662
NP_001287828; NP_004990; NP_001355065; NP_001355066; NP_001355067;
	NP_001355068; NP_001355069; NP_001355794; NP_001355795
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Unconventional myosin-VI, is a protein that in humans is coded for by MYO6. Unconventional myosin-VI is a myosin molecular motor involved in intracellular vesicle and organelle transport.