MYO7A

MYO7A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PVL
Identifiers
Aliases	MYO7A, DFNA11, DFNB2, MYOVIIA, MYU7A, NSRD2, USH1B, myosin VIIA
External IDs	OMIM: 276903; MGI: 104510; HomoloGene: 219; GeneCards: MYO7A; OMA:MYO7A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,215,241 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	97,768,731 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; left testis; ; right lobe of liver; ; right testis; ; anterior pituitary; ; spleen; ; paraflocculus of cerebellum; ; frontal pole;
	Top expressed in
	fourth ventricle; ; choroid plexus of fourth ventricle; ; Ileal epithelium; ; stroma of bone marrow; ; adrenal gland; ; yolk sac; ; retinal pigment epithelium; ; choroidal fissure; ; Epithelium of choroid plexus; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; spectrin binding; protein homodimerization activity; protein domain specific binding; ADP binding; calmodulin binding; microfilament motor activity; protein binding; actin binding; cytoskeletal motor activity; ATP binding; microtubule motor activity; microtubule binding; actin filament binding; protein-containing complex binding; protein N-terminus binding;
Cellular component	cytosol; photoreceptor inner segment; melanosome; photoreceptor outer segment; stereocilium; photoreceptor connecting cilium; microvillus; lysosomal membrane; cell cortex; apical plasma membrane; myosin VII complex; upper tip-link density; cytoskeleton; myosin complex; synapse; cytoplasm; stereocilium base;
Biological process	sensory perception; inner ear receptor cell stereocilium organization; pigment granule localization; sensory perception of light stimulus; post-embryonic animal organ morphogenesis; hearing; mechanoreceptor differentiation; pigment granule transport; auditory receptor cell stereocilium organization; phagolysosome assembly; inner ear auditory receptor cell differentiation; cell projection organization; equilibrioception; inner ear morphogenesis; eye photoreceptor cell development; phagocytosis; inner ear development; inner ear receptor cell differentiation; intracellular protein transport; lysosome organization; visual perception; actin filament-based movement; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	4647
	17921
	ENSG00000137474
	ENSMUSG00000030761
	Q13402
	P97479
	NM_000260; NM_001127179; NM_001127180; NM_001369365
	NM_001256081; NM_001256082; NM_001256083; NM_008663
	NP_000251; NP_001120652; NP_001356294
	NP_001243010; NP_001243011; NP_001243012; NP_032689
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin VIIA is protein that in humans is encoded by the MYO7A gene. Myosin VIIA is a member of the unconventional myosin superfamily of proteins. Myosins are actin binding molecular motors that use the enzymatic conversion of ATP - ADP + inorganic phosphate (Pi) to provide the energy for movement.

Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. Myosin VIIA is an unconventional myosin with the longest tail (1360 aa). The tail is expected to dimerize, resulting in a two-headed molecule. Unconventional myosins have diverse functions in eukaryotic cells and are primarily thought to be involved in the movement or linkage of intra-cellular membranes and organelles to the actin cytoskeleton via interactions mediated by their highly divergent tail domains.

MYO7A is expressed in a number of mammalian tissues, including testis, kidney, lung, inner ear, retina and the ciliated epithelium of the nasal mucosa.