Myocardin

MYOCD
Identifiers
Aliases	MYOCD, MYCD, myocardin, MGBL
External IDs	OMIM: 606127; MGI: 2137495; HomoloGene: 17043; GeneCards: MYOCD; OMA:MYOCD - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	12,768,949 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	65,160,815 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; saphenous vein; ; cardiac muscle tissue of right atrium; ; right ventricle; ; nipple; ; urethra; ; right coronary artery; ; superficial temporal artery; ; ascending aorta; ; smooth muscle tissue;
	Top expressed in
	ascending aorta; ; aortic valve; ; tunica media of zone of aorta; ; umbilical cord; ; myocardium of ventricle; ; interventricular septum; ; atrium; ; vas deferens; ; migratory enteric neural crest cell; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; R-SMAD binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; histone deacetylase binding; core promoter sequence-specific DNA binding; protein binding; histone acetyltransferase binding; cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	cellular component maintenance; positive regulation of transforming growth factor beta receptor signaling pathway; response to hypoxia; regulation of transcription, DNA-templated; negative regulation of cyclin-dependent protein serine/threonine kinase activity; urinary bladder development; regulation of transcription by RNA polymerase II; vascular associated smooth muscle cell differentiation; cardiac ventricle development; regulation of cell growth by extracellular stimulus; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; smooth muscle cell differentiation; transcription, DNA-templated; regulation of phenotypic switching; vasculogenesis; positive regulation of transcription, DNA-templated; uterus development; negative regulation of skeletal muscle cell differentiation; negative regulation of cardiac muscle cell apoptotic process; heart development; muscle cell differentiation; negative regulation of amyloid-beta clearance; positive regulation of smooth muscle cell differentiation; regulation of myoblast differentiation; regulation of histone acetylation; positive regulation of cell population proliferation; negative regulation of myotube differentiation; positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; positive regulation of cardiac vascular smooth muscle cell differentiation; positive regulation of cardiac muscle cell differentiation; ventricular cardiac muscle cell differentiation; positive regulation of DNA binding; lung alveolus development; digestive tract development; positive regulation of smooth muscle contraction; cardiocyte differentiation; ductus arteriosus closure; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; regulation of smooth muscle cell differentiation; transcription by RNA polymerase II; cardiac muscle cell differentiation; positive regulation of gene expression; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell migration; negative regulation of platelet-derived growth factor receptor-beta signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	93649
	214384
	ENSG00000141052
	ENSMUSG00000020542
	Q8IZQ8
	Q8VIM5
	NM_001146312; NM_001146313; NM_153604; NM_001378306
	NM_145136; NM_146386
	NP_001139784; NP_705832; NP_001365235
	NP_660118; NP_666498
	Wikidata
View/Edit Human	View/Edit Mouse

Myocardin is a protein that in humans is encoded by the MYOCD gene.

Myocardin is a smooth muscle cell and cardiac muscle cell-specific transcriptional coactivator of serum response factor (SRF). When expressed in smooth muscle precursor cells and abnormally in nonmuscle cells, myocardin can induce smooth muscle cell differentiation. Myocardin can also function in the differentiation of myocardial cells.