MYOM1

MYOM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R15, 2Y23, 2Y25, 3RBS
Identifiers
Aliases	MYOM1, SKELEMIN, myomesin 1
External IDs	OMIM: 603508; MGI: 1341430; HomoloGene: 31196; GeneCards: MYOM1; OMA:MYOM1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	3,219,968 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	71,433,851 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; glutes; ; apex of heart; ; gastrocnemius muscle; ; triceps brachii muscle; ; left ventricle; ; vastus lateralis muscle; ; right auricle of heart;
	Top expressed in
	triceps brachii muscle; ; temporal muscle; ; muscle of thigh; ; sternocleidomastoid muscle; ; digastric muscle; ; triceps surae; ; gastrocnemius muscle; ; medial head of gastrocnemius muscle; ; vastus lateralis muscle; ; tibialis anterior muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of muscle; protein binding; protein homodimerization activity; identical protein binding; actin filament binding; muscle alpha-actinin binding; structural molecule activity conferring elasticity; kinase binding;
Cellular component	cytoplasm; myosin filament; sarcomere; striated muscle myosin thick filament; Z discdkac; M band; striated muscle thin filament;
Biological process	muscle contraction; extraocular skeletal muscle development; striated muscle contraction; actin filament organization; sarcomere organization; striated muscle myosin thick filament assembly; positive regulation of gene expression; protein kinase A signaling; positive regulation of protein secretion; skeletal muscle thin filament assembly; skeletal muscle myosin thick filament assembly; cardiac myofibril assembly; cardiac muscle tissue morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	8736
	17929
	ENSG00000101605
	ENSMUSG00000024049
	P52179
	Q62234
	NM_003803; NM_019856
	NM_001083934; NM_010867
	NP_003794; NP_062830
	NP_001077403; NP_034997
	Wikidata
View/Edit Human	View/Edit Mouse

Myomesin-1 is a protein that in humans is encoded by the MYOM1 gene. Myomesin-1 is expressed in muscle cells and functions to stabilize the three-dimensional conformation of the thick filament. Embryonic forms of Myomesin-1 have been detected in dilated cardiomyopathy.