Magüi Serna
| Country (sports) | Spain | 
|---|---|
| Residence | Las Palmas | 
| Born | 1 March 1979 Las Palmas  | 
| Height | 1.67 m (5 ft 5+1⁄2 in) | 
| Turned pro | 1996 | 
| Retired | 2006 | 
| Plays | Left-handed (one-handed backhand) | 
| Prize money | $2,065,291 | 
| Singles | |
| Career record | 329–256 | 
| Career titles | 3 WTA, 6 ITF | 
| Highest ranking | No. 19 (12 January 2004) | 
| Grand Slam singles results | |
| Australian Open | 3R (1997, 2002) | 
| French Open | 4R (1998, 2003) | 
| Wimbledon | QF (2000) | 
| US Open | 4R (1997, 2000) | 
| Doubles | |
| Career record | 116–144 | 
| Career titles | 2 WTA, 1 ITF | 
| Highest ranking | No. 25 (5 July 2004) | 
| Grand Slam doubles results | |
| Australian Open | SF (2002) | 
| French Open | 3R (2000, 2002) | 
| Wimbledon | 3R (2001) | 
| US Open | 2R (2000, 2001) | 
| Team competitions | |
| Fed Cup | 10–10 | 
María Luisa ("Magüi") Serna Barrera (Spanish pronunciation: [maˈɾi.a ˈlwisa ˈmaɣwi ˈseɾna βaˈreɾa]; born 1 March 1979) is a former tennis player from Spain.
She started competing on the ITF Circuit as from 1993, and joined the WTA Tour in 1996. On 12 January 2004, she reached her career-high singles ranking of world No. 19.
Serna produced an upset by defeating Justine Henin in the 2001 Scottsdale tournament, 7–6, 7–6.