Malonic aciduria

Malonic aciduria
Other namesMalonyl-CoA decarboxylase deficiency, classic CMAMMA
Malonyl-CoA

Malonic aciduria or malonyl-CoA decarboxylase deficiency (MCD) is an autosomal-recessive metabolic disorder caused by a genetic mutation that disrupts the activity of Malonyl-CoA decarboxylase. This enzyme breaks down Malonyl-CoA (a fatty acid precursor and a fatty acid oxidation blocker) into acetyl-CoA and carbon dioxide.

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