Manchester United F.C. 1–6 Manchester City F.C.

In the 2011–12 Premier League season, the first game between Manchester United and Manchester City took place at Old Trafford, Manchester, on 23 October 2011. The fixture was both teams' ninth game of the season. City won the match 6–1, their biggest ever win in the Manchester derby, and their biggest win at Old Trafford since they won 5–0 in 1955. This was the first time in the clubs' history that the first and second place faced off in the Manchester derby.

In the match itself, Mario Balotelli opened the scoring in the 22nd minute, revealing a message on his undershirt that read "Why Always Me?" in reference to several off-the-field stories that were being run about him at the time. City led at the break, and in the 47th minute Jonny Evans was given a red card for a foul on Balotelli, who then scored his second in the 60th minute, and Sergio Agüero made it three shortly after. United scored a consolation goal through Darren Fletcher, but City scored three in injury time, with Edin Džeko scoring two and assisting David Silva, the recipient of the man of the match award. The game came to be regarded as one of the first glimpses that dominance in English football had shifted from one side of Manchester to the other.