María de Toledo

María de Toledo or María Álvarez de Toledo or María Álvarez de Toledo y Rojas (1490 – 11 May 1549) was a Spanish noblewoman and the first woman in the Americas with the title of Vicereine and regent of the Spanish Colony of Santo Domingo, present day Dominican Republic. She was the most powerful and highest-ranking noble in America in the 16th century and a defender of the liberties of the indigenous people in the Hispaniola.

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